Quantitative Modeling in Toxicology

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Governments around the world are passing laws requiring industry toassess the toxicity of the chemicals and products they produce, butto do so while reducing, refining, or even replacing testing onanimals. To meet these requirements, experimental toxicologists andrisk assessors are adopting quantitative approaches and computersimulations to study the biological fate and effects of chemicalsand drugs.

In Quantitative Modeling in Toxicology leading expertsoutline the current state of knowledge on the modeling of dose,tissue interactions and tissue responses. Each chapterdescribes the mathematical foundation, parameter estimation,challenges and perspectives for development, along with thepresentation of a modeling template. Additionally, tools andapproaches for conducting uncertainty, sensitivity and variabilityanalyses in these models are described. Topics coveredinclude: * the quantitative models of pharmacokinetics of individualchemicals and mixtures * models for toxicant-target tissue interaction. * models for cellular, organ, and organism responses. * approaches, tools and challenges for model application andevaluation

A website containing computer codes accompanies the book to helpthe reader reconstruct the models described and discussed in thevarious chapters.

Quantitative Modeling in Toxicology serves as anessential reference source and tool box for risk assessors andresearchers and students in toxicology, public health,pharmacology, and human toxicology interested in developingquantitative models for a better understanding of dose-responserelationships.